Cartridge-based autoinjectors: SHL Medical and GRAM’s integrated approach to LVSC delivery
October 06 2025
![[.jpg] <p><span lang="EN-US" class="TextRun SCXW810655 BCX0" style=" alignment-baseline: auto; animation: 0s ease 0s 1 normal none running none; backface-visibility: visible; baseline-shift: 0px; border-image: none 100% / 1 / 0 stretch; border-color: rgb(0, 0, 0); border-collapse: separate; border-width: 0px; border-style: none; border-spacing: 0px; border-radius: 0px; box-decoration-break: slice; box-shadow: none; box-sizing: content-box; break-after: auto; break-before: auto; break-inside: auto; caption-side: top; clear: none; clip: auto; clip-path: none; clip-rule: nonzero; color: rgb(0, 0, 0); color-interpolation: srgb; color-interpolation-filters: linearrgb; color-rendering: auto; columns: auto; column-fill: balance; column-rule: 0px rgb(0, 0, 0); column-span: none; contain: none; content: normal; counter-increment: none; counter-reset: none; counter-set: none; cursor: text; direction: ltr; display: inline; dominant-baseline: auto; empty-cells: show; fill: rgb(0, 0, 0); fill-opacity: 1; fill-rule: nonzero; filter: none; flex: 0 1 auto; flex-flow: row; float: none; flood-color: rgb(0, 0, 0); flood-opacity: 1; font-family: WordVisi_MSFontService, Tenorite, Tenorite_EmbeddedFont, Tenorite_MSFontService, sans-serif; font-feature-settings: normal; font-kerning: none; font-size-adjust: none; font-stretch: 100%; font-synthesis: weight style small-caps; font-variant-ligatures: none; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-alternates: normal; font-variant-position: normal; grid-area: auto; grid: none; height: auto; hyphens: manual; image-orientation: from-image; image-rendering: auto; lighting-color: rgb(255, 255, 255); line-break: auto; line-height: 20.85px; list-style: outside none disc; marker: none; mask: none; mask-type: luminance; max-height: none; max-width: none; min-height: 0px; min-width: 0px; object-fit: fill; object-position: 50% 50%; opacity: 1; order: 0; outline: rgb(0, 0, 0) none 0px; outline-offset: 0px; overflow-wrap: break-word; overflow: visible; page: auto; perspective: none; perspective-origin: 0px 0px; pointer-events: auto; position: static; quotes: auto; resize: none; ruby-align: space-around; ruby-position: over; shape-image-threshold: 0; shape-margin: 0px; shape-outside: none; shape-rendering: auto; speak: normal; stop-color: rgb(0, 0, 0); stop-opacity: 1; stroke: none; stroke-dasharray: none; stroke-dashoffset: 0px; stroke-linecap: butt; stroke-linejoin: miter; stroke-miterlimit: 4; stroke-opacity: 1; stroke-width: 1px; tab-size: 8; table-layout: auto; text-align-last: auto; text-anchor: start; text-combine-upright: none; text-decoration-line: initial; text-decoration-color: rgb(0, 0, 0); text-emphasis: none rgb(0, 0, 0); text-emphasis-position: over; text-orientation: mixed; text-overflow: clip; text-rendering: auto; text-shadow: none; text-size-adjust: auto; text-underline-position: auto; touch-action: auto; transform: none; transform-origin: 0px 0px; transform-style: flat; transition: all; unicode-bidi: normal; vertical-align: baseline; visibility: visible; -webkit-border-image: none; -webkit-box-align: stretch; -webkit-box-decoration-break: slice; -webkit-box-flex: 0; -webkit-box-ordinal-group: 1; -webkit-box-orient: horizontal; -webkit-box-pack: start; -webkit-font-smoothing: auto; -webkit-line-clamp: none; "><span class="NormalTextRun SCXW810655 BCX0">SHL Medical’s Maggie 5.0 cartridge-based autoinjector designed for LVSC delivery while prioritizing patient usability.</span></span></p>](https://cdn.bfldr.com/DTG6CG68/at/vc5b5cq53tp9wkwg6r5995rw/cartridge-based-autoinjectors-lvsc-delivery.jpg?width=480&auto=webp&format=webp)
Endpoints’ Manufacturing Day brought together industry innovators for an insightful conversation on cartridge-based drug delivery devices and large-volume subcutaneous (LVSC) delivery, featuring perspectives from SHL Medical and Contract Development and Manufacturing Organization (CDMO) Grand River Aseptic Manufacturing (GRAM). The session explored not only the technical nuances of developing cartridge-based systems, but also the power of partnership in bringing LVSC solutions to market.
Delivery systems: Innovation with usability in mind
SHL Medical, a pioneer in self-injection devices, highlighted the Maggie® 5.0 mL cartridge-based autoinjector during the session. Incorporating SHL Medical’s proprietary Needle Isolation Technology (NIT®), Maggie 5.0 is designed to enable LVSC delivery without compromising usability. By eliminating manual needle attachment, the device aims to provide patients with a more intuitive and safer injection experience.
As Vince Masciopinto, Customer Solutions Director at SHL Medical, explained, Maggie was developed in anticipation of future market needs. Its introduction reflects how SHL Medical invests early in device innovation and supporting infrastructure, enabled by the company’s vertical integration and deep industry expertise, to close industry gaps in large-volume autoinjector technologies. This approach aligns with SHL Medical’s broader strategy: combining engineering foresight with flexible development pathways, patient safety, and robust technology to address the shifting demands of at-home administration and biologic therapies.
![[.gif] NIT-20250708](https://cdn.bfldr.com/DTG6CG68/at/x76n64c9wm4kg85sn6zmv6r/NIT-20250708.gif?width=480&auto=webp&format=webp)
Fill and finish: Excellence meets collaboration
On the manufacturing side, GRAM provides fill and finish services for sterile injectable biologics, operating 500,000 square feet of GMP space to support drug development and scalable manufacturing. Tyler BeVier, Director of Drug Product Manufacturing at GRAM, emphasized the complexity of cartridge filling, noting critical factors such as equipment compatibility, sterilization techniques, stopper designs, and process validation.
GRAM’s recent investments in 5.0 mL cartridge capacity respond directly to the growing demand for LVSC delivery, where larger format containment introduces nuances and requires additional control, from maintaining container closure integrity to managing headspace and minimizing risk of variability across the fill-finish process.
Key lessons for pharma in LVSC delivery
The partnership between SHL Medical and GRAM demonstrates how aligning device development with manufacturing readiness can mitigate risks and accelerate delivery timelines for pharma partners.
• Integrated solutions: Together, SHL Medical and GRAM provide an established, streamlined supply chain for large-volume autoinjectors, helping pharma reduce time-to-market and limit upfront capital investment.
• Patient-first design: Both companies anchor their innovations in end-user needs, supporting self-administration and improving usability for patients requiring complex therapies.
• Expert collaboration: SHL Medical and GRAM’s combined experience and expertise enable smooth implementation of new technologies, reducing risk and building on proven success across multiple programs.
• Flexible pathways: SHL Medical’s infrastructure and GRAM’s flexible manufacturing allow pharma partners to select the optimal balance between proprietary device development and established platform adaptations, tailored to unique product and regulatory requirements.
Looking ahead
As drug delivery continues to evolve, the importance of early alignment will only grow. The collaboration between SHL Medical and GRAM stands out as a model for how partnership-driven approaches can advance patient-focused innovation and operational excellence, ensuring cartridge-based autoinjectors for LVSC therapies move swiftly, safely, and reliably toward the patients who need them most.
Check out GRAM’s takeaways and watch the full webinar on our channel.