Enlarging the volume of subcutaneous autoinjections

Summary

Moving autoinjectors beyond the traditional 2.0 mL range introduces new considerations for both device design and patient experience. This article explores how SHL Medical’s Needle Isolation Technology (NIT) enables larger-volume cartridge-based autoinjectors while maintaining a simple, needle-hidden injection experience. Using Maggie, which has since evolved into Magnitude, as a case study, the article examines how increasing delivery volumes and longer injection times affect device design and usability. It also considers how established device technologies and platform approaches can provide a foundation for further development in larger-volume self-injection.

Key takeaways

• NIT allows cartridge-based autoinjectors to maintain a hidden-needle design while providing control over cannula gauge and length to support different injection time and depth requirements. 
• Human factors research with Maggie found high ease-of-use ratings across key handling steps, supporting the usability of larger-volume autoinjectors. 
• Preliminary usability studies found no significant changes in device positioning, orientation, or needle-cover engagement over simulated injection times of up to 60 seconds.  
• SHL Medical’s platform-based approach allows established device technologies and manufacturing infrastructure to be leveraged as larger-volume autoinjectors are developed. 

Document details

• Format: Article
• Author/Spokesperson:
  Gary Calderwood, Product Manager, SHL Medical
  Raluca Ganea, PhD, Clinical Affairs Manager, SHL Medical
  Gene Rhode Fuensalida Pantig, Senior Scientific Communications Specialist, SHL Medical
• Page count: 6 pages
• Estimated read time: ~12–13 minutes